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KMID : 1007420100080020133
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Mood and Emotion
2010 Volume.8 No. 2 p.133 ~ p.137
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Incidence Rate and Risk Factors of Valproate-induced Thrombocytopenia in Psychiatric Inpatients：A Retrospective Chart Review Study
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Kwon Yong-Gil
Choi Jin-Hee
Chung Moon-Yong
Chung Hae-Kyoung
Kim Tae-Yong
So Hyung-Seok
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Abstract
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Objectives：This study was conducted to investigate the incidence and risk factors of thrombocytopenia in psychiatric inpatients taking valproate.
Methods：We analyzed the data of 132 patients taking valproate from electronic medical records. The incidence of thrombocytopenia was estimated, and the patients were divided into the thrombocytopenia group and the non-thrombocytopenia group. We tested the differences of demographic characteristics and clinical variables between both groups. Finally, binary logistic regression analysis was done to test the effect of potential risk factors on thrombocytopenia.
Results：Fifteen (11.4%) patients experienced thrombocytopenia. The use of topiramate was associated with thrombocytopenia. The thrombocytopenia group showed lower platelet count at admission, higher level and dose of valproate compared to the non-thrombocytopenia group. Logistic regression analysis showed that the risk of thrombocytopenia substantially increased with the use of topiramate,platelet count below 200×109/L at admission, and valproate level above 100 μg/mL checked at the point of nadir platelet count.
Conclusion：To reduce the risk of thrombocytopenia in psychiatric inpatients taking valproate,checking the platelet count before treatment and maintaining the level of valproate not to exceed 100 μg/mL are advised.
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KEYWORD
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Valproate, Adverse effect, Thrombocytopenia, Platelet, Topiramate
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